1Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, Maharashtra, India
2Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, Maharashtra, India-413736
3Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, India
4Department of Pharmaceutical Chemistry, College of Pharmacy, Chincholi, Maharashtra, India
5Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, India
*Corresponding Author E-mail: ravisaudagaur@yahoo.com
Online published on 19 June, 2014.
Selective estrogen receptor modulators are the class of a chemical compounds acting on a estrogen receptors. These are selectively inhibit or stimulate the estrogen like actions in various tissues. SERMs play a key role in breast cancer chemoprevention. These agents antagonize estrogens in some tissues and mimic their action in others. The mechanism for tissue selectivity appears to be related to differences in their molecular and three-dimensional structures, which affect the transcriptional activity of the activated estrogen receptor. For example, tamoxifen and toremifene act as estrogen antagonists in breast tissue and as estrogen agonists in the endometrium. The present review article is directed towards highlighting the importance of SERMs in treatment of breast cancer.
Selective Estrogen Receptor Modulators (SERM'S), Breast cancer, hormone replacement therapy (HRT)
