1Department Pharmaceutical Chemistry, Srinivas College of Pharmacy, Mangalore -574142, Karnataka, India
2Medicinal Chemistry Research Lab, Bapatla College of Pharmacy, Bapatla-522101, Andhrapradesh, India
3Department Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu-523167, Andhrapradesh, India
4Department of Pharmaceutics, Rahul Institute of Pharmaceutical Science & Research, Chirala-523157, Andhra Pradesh, India
*Corresponding Author E-mail:
Online published on 19 June, 2014.
A series of 1-(4-substitutedphenyl)-3-phenyl-1H-pyrazole-4-carbaldehyde 4a-e has been synthesized and tested for their anti-inflammatory and analgesic activities. Formation of the pyrazole derivatives was achieved by treating vilsmeier-haack reagent. The newly synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to indomethacin, flufenamic acid and diazepam as standard drugs. The detailed synthesis, spectroscopic and toxicity data are reported.
Pyrazole, anti-inflammatory activity, analgesic activity
