Formulation and Evaluation of Oral Controlled Release Matrix Tablets of Propranolol Hydrochloride

The aim of the present study was to develop Propranolol Hydrochloride Oral Controlled release tablets to maintain constant therapeutic levels of the drug for over 12 hrs. Locust bean gum, Kollidon SR, Karaya gum were used as polymers. All the formulations were passed various physicochemical evaluation parameters such as Bulk Density, Tapped Density, Carr's Index, Hausner's Ratio, Angle of Repose, Weight Variation, Hardness, Thickness, Friability and Drug Content. From the dissolution studies it was evident that the formulation F7 showed better and desired drug release pattern i.e., 98.56% in 12 hours. It contains the Karaya gum as polymer. It followed Zero order release kinetics mechanism.