Protective effect of Ventilago maderaspatana bark extract against various ulcer models in rats

Gastric ulcer is a common gastrointestinal disorder, and traditional medicines have been used for centuries to treat various ailments, including gastric ulcer. Ventilago maderaspatana bark is a traditional remedy used in Ayurvedic and Malay medicine for the treatment of gastric ulcer. This study aimed to investigate the anti-ulcer potential of the ethanolic extract of Ventilago maderaspatana bark against in vivo indomethacin- and cold restrained stress-induced gastric ulcer, and pylorus ligation assays.

The ethanolic extract of Ventilago maderaspatana bark was administered orally at doses of 100, 200 and 400 mg/kg. The anti-ulcer potential of the extract was evaluated against in vivo indomethacin- and cold restrained stress-induced gastric ulcer, and pylorus ligation assays. The ulcer index, pH of gastric acid, volume of gastric juice, free and total acidities were measured.

The extract of Ventilago maderaspatana bark (400 mg/kg) significantly (P<0.05) reduced the ulcer index in all assays used. Furthermore, the extract significantly increased the pH of gastric acid while reducing the volume of gastric juice and free and total acidities.

The ethanolic extract of Ventilago maderaspatana bark has significant anti-ulcer potential against in vivo indomethacin- and cold restrained stress-induced gastric ulcer, and pylorus ligation assays. These findings support the traditional use of Ventilago maderaspatana bark in the treatment of gastric ulcer. Further studies are required to elucidate the mechanisms underlying its anti-ulcer potential.