1Master of Pharmacy, Department of Pharmacology, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, India, 412301
2Final Year Bachler of Pharmacy, Sudarshan Education Foundations SARSAM College of Pharmacy A/P Palashiwadi, Tal - Baramati, Dist - Pune, 412304
3Head of Department Department of Pharmacology, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, India, 412301
4Master of Pharmacy, Department of Pharmacology, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, India, 412301
In the present study we have selected antioxidants agents like Pioglitazone and Ascorbic acid were subjected for anti-cataract activity by in vitro glucose induced cataract model. Cataract is an opacity within the clear natural crystalline lens of the eye that causes eyesight impairment over time. Ageing, free radical production, diabetes, and oxidative stress-induced protein denaturation are all factors that contribute to cataract formation. Antioxidants protect the eyes by minimizing the effects of free radicals. Using goat lenses, researchers tested the anti-cataract efficacy of -lipoic acid in vitro against glucose-induced caractogenesis. Clear isolated goat lenses are separated into nine experimental groups and cultured in produced aqueous humor. For a period of 24hours, 15μg/ml, 30μg/ml, and 60μg/ml of -lipoic acid are incubated simultaneously with glucose (55mM) and glucose (5.5mM). The typical medication is ascorbic acid (40μg/ml). The opacity of the lens is measured at the end of the incubation period.
Anti cataract, Anthocyanin, Ascorbic acid, Glucose, Antioxidant
