Asian Journal of Pharmaceutical Research
  • Year: 2024
  • Volume: 14
  • Issue: 2

Review paper on models for CNS stimulant drug screening

  • Author:
  • Komal D. Pol1,*, Pradnya N. Jagtap2, Vishakha Vikas Jagatap3, Shweta S. Bobade3, Vaishnavi P. More3, Ankita M. Kadam3, Pratibha Deshmukh3, Ashwini Kunjir3
  • Total Page Count: 5
  • Page Number: 148 to 152

1Master of Pharmacy, Department of Pharmacology, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, India, 412301

2Head of Department Department of Pharmacology, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, India, 412301

3Master of Pharmacy, Department of Pharmacology, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, India, 412301

*Corresponding Author E-mail: polkomal94@gmail.com

Online published on 25 July, 2024.

Abstract

Drugs called central nervous system (CNS) stimulants hasten both mental and physical functions. Narcolepsy and new born apnea are two disorders characterised by a lack of adrenergic stimulation that are treated with central nervous system stimulants. Moreover, the paradoxical effects of dextroamphetamine sulphate (Dexedrine) and methylphenidate (Ritalin) on attention-deficit hyperactivity disorder are invoked to justify their use (ADHD). The majority of CNS stimulants mimic the classic "fight or flight" condition linked to sympathetic nervous system activation and are chemically comparable to the neurohormone norepinephrine. The xanthines, including theophylline, and caffeine are more intimately connected to one another. A few more CNS stimulant class members do not belong to any particular chemical classes. A detailed analysis of CNS stimulant medications, their mechanisms of action, and in vivo CNS stimulant models is provided in the review on central nervous system stimulants.

Keywords

CNS stimulant, Actophotometer, Forced swim test, Open field test, Elevated plus maze