Asian Journal of Pharmaceutical Research

Tricyclic carbazole derivatives displayed excellent anticancer activities in literature. In this research work, we synthesized a series of some novel substituted carbazole carbamate derivatives and also evaluated their anticancer activity (IC₅₀) against human glioma U87MG cell line. Both 6^th position and N-ethyl substituted carbazole carbamate derivatives synthesized and tested for anticancer potential on human glioma U87MG cell line based on colorimetric MTT assay. SAR (structure activity relationship) study of all substituted carbazole carbamate derivatives also elaborated on the basis of in vitro anticancer activity (IC₅₀) results. Four carbazole integrated carbamates (27, 28, 30, 31) possesses excellent anticancer profile with IC₅₀ values 17.97 μM, 15.25 μM, 29.58 μM, and 23.80 μM respectively on U87MG glioma cell line. Both 6-substituted and N-ethyl based carbazole carbamate compounds displayed excellent in vitro anticancer activity on tested glioma cell line. The study of novel substituted carbazole tethered carbamate derivatives found potential anticancer profile against U87MG glioma cell line and can be fruitful for further development against brain tumour.