Estimation of Tadalafil in Tablet Dosage form by UV Spectrophotometric Method

For the measurement of tadalafil in tablet formulation, two straight forward, affordable, accurate, and exact UV and first derivative spectrophotometric techniques have been devised. Tadalafil exhibits zero crossover at 284nm in the first order derivative spectra (Method-B) and an absorbance peak at 284nm (Method-A). With these two techniques, Beer’s law is followed in the concentration range of 20–120 micrograms/mL. The analysis’s findings were statistically confirmed, and the recovery studies were deemed adequate. Their conclusions were unaffected by the prevalent excipients and additives.