Animal Models of Alcoholic Liver Disease and Non-Alcoholic Fatty Liver Disease

The alcoholic liver disease (ALD) and Non-alcoholic fatty liver disease include the lethal factors for chronic hepatic lipid deposition, inflammatory events to extensive fibrotic repair globally that is responsible for a major clinical contribution. Based on these findings, we observed that alcohol induced liver diseases (ALD) is caused by oxidant: antioxidant imbalance. As animal models and in vitro research have clarified the complex biochemical mechanisms involved, treatment with antioxidants, anti-inflammatory drugs and enzyme inhibitors that block alcohol metabolism has been explored. Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and is often linked to obesity, insulin resistance, and dyslipidemia. It is caused by adipose tissue failure, insulin signaling pathways, and inflammatory mediators. Preclinical models targeting these processes are crucial.