Asian Journal of Pharmaceutical Research

Transdermal drug delivery system specialists are continuing to investigate new methods for efficiently and painlessly transmitting better molecules in therapeutic quantities to overcome the challenges of the oral route, which are poor bioavailability due to first pass metabolism and receptiveness to produce rapid blood levels. Transdermal drug delivery improves therapeutic effectiveness and drug security by delivering drugs to specific sites, but spatial and temporal placement within the body is required to reduce both the size and number of doses required to achieve the goal of systemic medication via topical application to the intact skin surface. Transdermal patches deliver drugs for systemic effects at a controlled and predetermined rate. It is directly absorbed into the blood from the skin through diffusion. As there is a high concentration in the patch and a low concentration in the blood, the drug will diffuse continuously into the blood for a longer time to maintain a constant concentration of the drug in the blood flow. Novel carrier-mediated drug delivery systems include examples such as transdermal patches, Niosomes, Ethosomes, and liposomal drug delivery systems. The key factor of all TDDS is that the drug must be able to penetrate through skin in a sufficient quantity for the desired therapeutic effect.