Molecular Docking and Admet Studies of Nigella sativa Plant against Osteoporosis

Utilising docking of molecules and ADMET research, this investigation explores the possibility of Nigella sativa, or black seed, as a treatment for osteoporosis. Osteoporosis is a huge global public health concern since it considerably raises the menace of fractures and causes a diminution in bone density. Despite existing treatments, there remains a need for novel therapeutic agents with improved efficacy and safety profiles. Nigella sativa, renowned for its diverse pharmacological properties, emerges as a promising candidate for osteoporosis management. Through molecular docking analysis, the interaction between bioactive compounds present in Nigella sativa and key osteoporosis-related targets, like activator of kappa-β ligand receptor and osteoprotegerin was explored. The results reveal potential binding affinities and binding modes, suggesting the ability of Nigella sativa constituents to modulate osteoporosis-related pathways. Additionally, ADMET predictions provide valuable insights into the pharmacokinetic and toxicity profiles of Nigella sativa compounds.