Assessment of the Modulatory effects of Curcumin Co-Administration and Pretreatment on Granisetron Intestinal Permeability using a Goat Membrane Model

The present study aimed to investigate the effects of co-administration of varying concentrations of curcumin (2, 6, 10, 14, and 18mg) and pretreatment at different time intervals (30, 60, and 120minutes) on the goat intestinal permeability of Granisetron. The experiments were conducted using a Franz diffusion cell in phosphate buffer at pH 7.4. Permeability data were analyzed to determine the percentage cumulative drug release (%CDR), apparent permeability coefficient (Papp), flux (J), and enhancement ratio (ER). The co-administration of curcumin with Granisetron HCl was observed to significantly reduce the membrane permeability of Granisetron HCl. Similarly, pretreatment with curcumin led to a notable decrease in Granisetron HCl permeability. These findings suggest that curcumin does not facilitate increased permeability or bioavailability of Granisetron HCl, and pretreatment with curcumin has a further detrimental effect on its membrane permeability.