Synthesis, Characterization and Its Biological Evaluation of Some Novel 4-Thiazolidinone and 2-Azetidinone Derivatives

In the present study, a series of 4-thiazolidinones and 2-azetidinone derivatives were synthesized by refluxing Schiff bases with different aromatic aldehydes. Schiff bases were synthesized by reaction of nicotinamide with hydrazine hydrate. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectroscopy and elemental analysis. These compounds were screened for anti-tubercular, anti-convulsant antibacterial and anti-fungal activities. Anti-Tubercular activity mycobacterium tuberculosis and MIC level of the compounds was less than 6.25 μg/ml. Compound IIIa, IIId, IVa and IVd exhibited good Anti-convulsant activity. Compound IIIa, IIIc IIId, IVa, IVc and IVd exhibited good antibacterial activity on Gram-positive and Gram-negative microorganisms. All the synthesized compounds exhibited good Antifungal activity.