Designing and Optimization of medicated chewing gum of Ambroxol HCl by using 3² Factorial design

The present work deals with optimization of designed MCG, so that the best possible set of parameters affecting result can be selected to get the desired output. In this report nine batches of formulations (F1-F9) prepared and studied. Two variables were selected for the formulations in which first was concentration of elastomer and other was concentration of softener. The mathematical models developed for all the dependent variables using statistical analysis software Design experts 8.0.1. Percent Drug release of various formulation F2, F5, F8 and F9 was found to be 95.31, 98.74, 88.18 and 91.74. The highest Percent of Drug release among all is of F5.