Fast Disintegrating Tablets of Nevirapine

The present research work was investigated on fast disintegrating tablets of an anti-retroviral drug Nevirapine. Nevirapine is non-nucleoside reverse transcriptase inhibitor (NNRTI) class of antiretrovirals and belongs to bcs class 2. Mother to child transmission of HIV during pregnancy can be avoided by taking nevirapine tablets. The rate limiting parameter for poor bioavailability of Nevirapine was attributed due to its poor dissolution and solubility. The formulation development of Nevirapine was conducted with different concentrations of superdisintegrants sodium starch glycollate and croscarmellose sodium. Fast disintegrating tablet showed a significant influence on disintegration and dissolution studies. Effect of superdisintegrant on dispersion time and in vitro release has been studied. Fast disintegrating tablets containing sodium starch glycolate showed excellent in vitro dispersion time and drug release as compared to other formulations. The cumulative % drug release profile of F-3 formulation was found to be maximum when compared with other formulations.