Asian Journal of Pharmaceutical Research

  • Year: 2017
  • Volume: 7
  • Issue: 2

Anti-Inflammatory activity of Ethanolic extract of Basella alba in acute and Sub-acute Model

  • Author:
  • Naidu Narapusetty1,, O. Sivaiah1, B. Balanasaraiah1, M. Haranadhbabu, B. Prasad1, B. Hosanna Crown1, Ch. M. M. Prasada Rao2
  • Total Page Count: 6
  • Page Number: 88 to 93

1Department of Pharmacology, Bellamkonda Institute of Technology and Sciences, Podili

2Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole

*Corresponding Author E-mail: narapusetty.naidu@gmail.com

Online published on 18 September, 2017.

Abstract

The present study is carried out to investigate the anti-inflammatory potential of Ethanolic extract of Basella alba (BA). Anti-inflammatory activity was evaluated by using Egg Albumin, Turpentine Oil and Formaldehyde as phlogistic agents. The animals were treated with doses 250mg/kg and 500mg/kg of extract and Diclofenac Sodium at a dose of 10mg/kg is used as a standard drug. The BA showed a significant anti-inflammatory activity in a dose dependent manner in all the models when compared with the standard treatment. The extract (500mg/kg) exhibited maximum antiinflammatory activity i.e., 46.25%, 44.30%, 46.40% (P<0.001) like standard Diclofenac 47.02%, 46.50%, 48.57% in Egg albumin, Turpentine oil and Formaldehyde induced methods respectively. Based on the above results, we conclude that the BA has significant anti-inflammatory activity and might prove efficacious for further design and development of agents with significant biological activity.

Keywords

Basella alba, anti-inflammatory activity, phlogistic agents