Synthesis, Characterization, Anti Microbial, Analgesic activities of 3-(3-Chlorophenyl)-5-Phenyl-4, 5-Dihydro-1, 2-Oxazole Derivatives

Novel Isoxazoles are prepared by treating chalcone derivatives from 3-Chloro acetophenone with hydroxyl amine hydro chloride, small amount of sodium acetate and ethanol. The chalcone were prepared by using the 3chloro Acetophenone with aromatic aldehydes in presence of NaOH followed by Clasein-Schmidt condensation reaction. All the synthesised compounds were characterized by using the IR, H¹ NMR spectroscopy. The biological evolution like anti bacterial and analgesic activity was performed for test compounds to identify the activity. Here the disc diffusion method performed to identify the anti bacterial activity by measuring of zone of inhibition in mm compared with standard streptomycin and analgesic activity by performing the tail immersion method measuring the percentage of inhibition compare with standard Paracetamol at dose of 100 mg/kg.