The emulsion solvent diffusion method was employed for the preparation of microcrystals of Tinidazole (TNZ). To achieve the combined effect of polymer and size reduction on the solubility of TNZ, the drug was formulated using constant concentrations of the surfactants such as PVP, PEG 400 and HPMC at different stirring speeds of (200,400,600) rpm. As it was noted that the speed of stirring is responsible for micronization of crystals, the speed of stirring was optimized to get uniform sized crystals. The effect of changing the type of polymer on the formation of TNZ microcrystals was investigated. Microcrystals were dried at room temperature. Particle size, saturation solubility, drug content, and dissolution characteristics were also investigated.
Tinidazole, Emulsion solvent diffusion, microcrystals, polymer effect, PVP, PEG 400 and HPMC
