Solid Dispersion: Recapitulation

The approach to improve dissolution rate of hydrophobic drug and enhance the bioavailability, solid dispersion is one of the promising approaches in which dispersion of one or more drug substances (API) in a hydrophilic carrier at solid state is used. Among all newly discovered chemical entities about 40% drugs are lipophilic and hence fail to reach the market due to poor water solubility. The review highlights the timeline of solid dispersion approach and summarizes the development over the years and its potentiality in the future.