Asian Journal of Pharmacy and Technology

The aim of the present investigation is to formulate and evaluate the controlled porosity osmotic pump tablets of zaltoprofen, with an aim to achieve zero order/near zero order release. Controlled release porosity osmotic pump tablets for zaltoprofen was prepared with osmogen by non aqueous granulation followed by semi permeable coating. The prepared tablets were evaluated with pre and post compression parameters. The effect of different parameters like effect of different concentrations of osmogens, effect of percent buildup of coat, influence of agitation intensity, effect of different pH on the drug release were also studied. Based on in vitro drug release studies the optimized formulation was selected. Finally investigated different drug release kinetics for the optimized formulation. It is clearly evident from in vitro release data; the formulated osmotic tablets drug release follows constant zero order release kinetics, until there is osmotic pressure inside the tablet which is suitable for the delivery of drugs having moderate water solubility.