Asian Journal of Pharmacy and Technology

  • Year: 2021
  • Volume: 11
  • Issue: 1

Synthesis of isoniazid from citric acid

1Dept of Pharmaceutical Chemistry, SND College of Pharmacy, Bhabhulgaon, Yeola

2Dept of Quality Assurance, Mahatma Gandhi Vidyamandir’s Pharmacy College, Nashik

*Corresponding Author E-mail: rutujatjadhav21@gmail.com

Online published on 27 April, 2021.

Abstract

Isoniazid is an organic compound. It is a first line drug used in prevention and treatment of tuberculosis also Isoniazid has an anti-depressant effect. Isonicotin hydrazine is also known as isoniazid. A process was developed for the preparation of isoniazid from citric acid via citrazinic acid 2, 6-dichloroisonicotinic acid, isonicotinic acid and ethyl isonicotinate. Yields and procedures in all steps were improved (1).

Keywords

Isoniazid, Citrazinic acid, Isonicotin, Anti-depressant, Tuberculosis