Manoharbhai Patel Institute of Pharmacy (B. Pharm), Kudwa, Gondia, Maharashtra, 441614
The objective of our work was to maximize the therapeutic efficacy of Atrovastatin by developing oil in water (o/w) nanoemulsion to increase its poor solubility and consequently enhance the oral bioavailability. The aim of investigation was to rectify the first-pass metabolism of Atorvastatin, using preparation of nanoemulsion as a prominent delivery system. Olive oil, surfactant (tween 80, tween 40, tween 20) and co-surfctants including polyethylene glycol was selected after solubility studies. Then pseudo-ternary phase diagram with surfactant/ cosurfactant ratio of 1:1, 2:1, 3:1 and 4:1 were constructed and spontaneous emulsification method. Titration method was used to optimize the Atorvastatin loaded nanoemulsions. The prepared nanoemulsion was characterized by globule size, refractive index, partition coefficient, viscosity, drug entrapment efficiency, in vitro drug release studies. Optimised nanoemulsion obtained was composed of olive oil (8.5 %w/w), tween 80 (11.5 %w/w) and water (80 %w/w). The results obtained showed an average globule size. The Optimized formulation showed an improvement in solubility of Atorvastatin. The use of pseudo-ternary phase diagram allows obtaining an optimal nanoemulsion with perfect stability for three months and a better solubilization capacity of Atorvastatin.
Nanoemulsion, Atorvastatin, Surfactant, Co-surfactant, Gastrointestinal tract, Pseudo ternary phase diagram, In-vitro drug release, O/w and w/o nanoemulsion
