Formulation and Evaluation of Cubosomal Gel of Silver Nitrate for Burn Treatment

In present study we enclosed on the formulation of a cubosomes a new nano carrier system, cubosomes, including with silver nitrate for increasing its therapeutic effectiveness. Silver nitrate in concentration of 0.5% solution in those ancient solutions, which can be used topically to treat burns healing. The nanocubosome were loaded-drug prepared by rotary evaporation technique and then freeze dried. The various technique were used for evaluation of prepared cubosomes such as light scattering, Transmission Electron Microscopy (TEM) was used. The parameters size, morphology, thermal behaviour as well crystallography respectively was evaluated. Further drug loading and encapsulation efficiency was evaluated using UV spectrophotometry. Silver nitrate loaded cubosomes were prepared and characterized results showing mean diameters of 86-106 nm with DLS. The TEM, PXRD data represent characteristic peaks of cubic nature which further confirmed that the freeze dried nanoformulations was in cubical form. DSC and PXRD analysis for drug loaded into cubosomes shows the lodeing upto 0.06 or 0.28% w/w. Thus, obtained physicochemical properties play vital role in the improvement of shelf life, therapeutic and toxicological profiles of nano formulations.