1A M Reddy Memorial College of Pharmacy, Petlurivaripalem, Narasaraopet, Andhra Pradesh, India
2Aditya College of Pharmacy, Surampalem, East Godavari (DT), Andhra Pradesh, India
The current study paying attention on the Investigation of hydrodynamically balanced regioselective restricted release DDS for a BCS class II drug using various polymers. At first, an analytical technique was established for the pharmaceutical compound, then the absorption maxima were identified, and a Standard plot was constructed with varying concentrations. The gas-generating agent, NAHCO3 was fine-tuned for optimal concentration. Subsequently, the formulation was created using varying amounts of polymers such as Hibiscus mucilage, Okra, Lannea Coromandelica gum, and Polyox WSR 303. Preformulation investigations and evaluations of flow characteristics revealed that all formulations exhibited favorable flow properties. The formulations underwent several pharmacopoeial tests, are uniformity of weight, thickness, hardness, friability. The vitro buoyancy, drug release patterns of the formulations were assessed through kinetic modeling. After conducting in vitro buoyancy and in vitro release experiments, it was determined that the combination of Lannea Coromandelica and Polyox WSR 303 exhibited the most favorable kinetics. The research indicated that utilizing a blend of natural and synthetic polymers is more advantageous for creating GRDDS. Natural polymers can maintain drug release over a specific timeframe before triggering a sudden release, whereas the combination of natural and synthetic polymers allows for controlled release at reduced concentrations. The most effective formulation, F12, was chosen for release kinetic investigations, demonstrating that F12 adhered to a non-fickian release mechanism as indicated by the graphs acquired.
Lafutidine, Regioselective drug delivery, Synthetic polymers, Natural gums, BCS classification
