Synthesis, Characterization, Anti-tubercular, Analgesic and Anti-Inflammatory Activities of New 2-Pyrazoline Derivatives

The compounds of different Pyrazoline derivatives were synthesized by cyclization of substituted chalcone derivatives in presence of hydrazine hydrate (a-e). All the synthesized compounds were characterized by spectral analysis (IR, MS and NMR). The REMA (Resazurin Microtiter Assay) plate method was used for anti-tuberculosis activity. The minimum inhibitory concentration (MIC) of the newly synthesized compound was tested against Mycobacterium tuberculosis H37RV. The Analgesic activity was performed by Acetic acid induced method. The Anti-inflammatory activity was performed by Carrageenan induced paw edema method.