Study on Taste Masking of Ranitidine HCl Using Ion Exchange Resin

The taste of a drug plays an important role in patient compliance. Ranitidine HCl is a Histamine blocker drug with bitter taste. The drug Ranitidine HCl was treated with a cation exchange resin, which forms complex with the drug and mask the bitterness of Ranitidine HCl. The loading process was optimized for the resin type, pH of loading solution and drug:resin ratio. The resin-drug complex was evaluated for taste by panel method. The rate of dissolution was studied and the drug had showed good release. These findings can be utilized to formulate a non bitter dosage form for Ranitidine HCl with good bioavailability.