Solubility Enhancement by Various Techniques based on Pharmaceutical and Medicinal Chemistry Approach: An Overview

Solubility is the property of a solid, liquid, or gaseous chemical substance called solute to dissolve in a solvent to form a homogeneous solution. Approximately 40% new molecular entities (NMEs) synthesized in pharmaceutical R&Ds with advanced combinatorial chemistry and computer aided drug designing (CADD) approaches suffer from poor solubility and bioavailability related issues. Drug with poor water solubility cause slow dissolution rates and generally show issues with bioavailability, particularly when administered via oral route. The purpose of this article is to present various techniques to enhance solubility by novel formulation techniques including Traditional approach (chemical modifications in the drug) and Medicinal chemistry approach (Lipinsky rule of five, Veber rule and QPSR-Quantitative structure property relationship).