New Spectrophotometric Determination of Cefaclor in Bulk Drug and Synthetic Mixture

A simple, economic and reproducible spectroscopic method has been developed for the determination of cefaclor API and in its pharmaceutical formulations. The spectroscopic method is based on the formation of complex with p–di methyl amino benzaldehyde reagent having absorbance maxima at 484.4 nm. Optimization of reaction was carried out with the factors: buffer strength, reaction time, stability of complex, molar ratio of drug: reagent. The Beer-Lambert's law was followed in the range of 2.5–15 μg/ml.