Three simple, sensitive and cost effective Spectrophotometric methods are developed for the determination of Atorvastatin calcium in pure and its pharmaceutical formulations. These methods are based on the oxidation of Atorvastatin calcium by ferric chloride in presence of o-phenanthroline (Method A) or 2, 2′bipyridyl (Method B) or potassium ferricyanide (Method C). The colored complex formed was measured at 509, 520 and 735.5 nm for method A, B and C respectively against the reagent blank prepared in the same manner. The optimum experimental parameters for the color production are selected. Beer's law is valid within a concentration range of 20–100 μg/ml, 30–150μg/ml and 10–50 μg/ml for method A, B and C respectively. The mean percentage recoveries are 99.82, 100.1, 99.86 for method A, B and C respectively. The developed methods are applied for the determination of Atorvastatin calcium in bulk and its pharmaceutical formulations without any interference from excipients.
Spectrophotometry, Atorvastatin calcium
