1Department of Chemistry, Nizam College, OU, Basheerbagh, Hyderabad-500001, Telangana, India.
2Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, Telangana, India.
The Co(II) metal (M) complex of 2,4-dichloro-N-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)benzohydrazide (L) was synthesized and characterized by elemental analysis, molar conductance, magnetic moment measurements, LC-MS, IR, TGA and UV spectral studies. Irving-Rossetti titration method was employed to determine the acid dissociation constant of ligand and the stability constant of Co(II) complex in 70% (v/v) DMF-water medium at 0.1 M KNO3 ionic strength and 303K temperature. The spectroanalytical data indicate the composition of the complexes to be 1:2 (ML2) with octahedral geometry. The ligand and the complex were screened for their antibacterial activity against Gram positive and Gram negative bacteria using agar well diffusion method.
Pyridoxal, Schiff base, Complex, Stability constant, Antibacterial activity
