Asian Journal of Research in Chemistry
  • Year: 2017
  • Volume: 10
  • Issue: 4

Synthesis and Molecular docking for Anti-Inflammatory and Anti Mitotic activities of (S)-(2-Methyl-4-(1-Phenyl-1h-Thieno/Furan [3, 2-C] Pyrazol-3yl) Piperazin-1-yl)(Pyridin-2-yl) Methanone

  • Author:
  • Ramu Surakanti1, Laxminarayana Eppakayala2,, Ramchander Merugu3, Venkat Reddy Pendyala2
  • Total Page Count: 5
  • Page Number: 582 to 586

1Rishitha Biosciences, North Hastinapuram, LB Nagar, Hyderabad, 500 074, Telangana, India

2Sreenidhi Institute of Science and Technology (Autonomous), Ghatkesar, Hyderabad, 501301, Telangana, India

3University College of Science, Mahatma Gandhi University, Nalgonda-508254, Telangana, India

*Corresponding Author E-mail: elxnkits@yahoo.co.in

Online published on 17 October, 2017.

Abstract

The synthesis of piperazine derivatives containing thiophene and oxazole is described. They were prepared from (Z)-3-bromo-N’-phenylthiophene/furan-2-carbohydrazonoyl chloride in a series of steps. All the synthetic compounds are characterized by spectral analyses. They were further analyzed for anti-inflammatory and antimitotic activity and the results are discussed.

Keywords

Synthesis, anti inflammatory activity, antimitotic activity