Asian Journal of Research in Chemistry
  • Year: 2017
  • Volume: 10
  • Issue: 4

Microwave assisted facile synthesis of 5-Aryl-5, 6-dihydro-1-methyl-3propyl-1H-pyrazolo [4, 3-d]pyrimidin-7(4H)-ones and docking for antiinflammatory activity

  • Author:
  • Siddhartha Marupati1, Laxminarayana Eppakayala2,, Ramesh Malothu3, Ramchander Merugu4, Venkat Reddy Pendyala2
  • Total Page Count: 4
  • Page Number: 593 to 596

1Vardhaman College of Engineering, Shamshabad, Hyderabad, 500 018, Telangana, India.

2Sreenidhi Institute of Science and Technology (Autonomous) Yamnampet, Ghatkesar, Hyderabad-501301, Telangana, India

3Jawaharlal Nehru Technological University, Kakinada-533 003, Andhra Pradesh, India

4University College of Science, Mahatma Gandhi University, Nalgonda-508254, Telangana, India

*Corresponding Author E-mail: elxnkits@yahoo.co.in

Online published on 17 October, 2017.

Abstract

5-Aryl-5, 6-dihydro-1-methyl-3-propyl-1H-pyrazolo[4, 3-d]pyrimidin-7(4H)-ones (2a-e) were synthesized by the condensation of 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide with different aldehydes using microwave irradiation. All title compounds were characterized by 1H NMR and mass spectra. Molecular docking of 5cox with ligand showed that the title compound was a potent anti-inflammatory compound.

Keywords

Synthesis, pyrazoles, pyrimidines, microwave, docking