Catalyst Free Synthesis of Imines and their Biological Evaluation.

An efficient route for the synthesis of aromatic imines has been developed using simple protocol at room temperature. The synthesis was completed by using commercially available starting material. Here we synthesized fourteen imines derivatives with excellent yield. Synthesized intermediates showed potent inhibition of Mycobacterium tuberculosis. The Schiff's bases shown drug like properties and is a good starting point for further exploration in antituberculosis drug discovery.