Synthesis and In Vitro Anti-inflammatory Activity of 5-arylidene-1-[(2 (Methyl suphonyl amino) thiazol-4-yl) methyl]-2-thioxoimidazolidin-4-ones.

One-pot multicomponent condensation carried for obtaining 5-arylidene-1-[(2-(methylsuphonyl-amino)thiazol-4-yl)-methyl]-2-thioimidazolidin-4-ones using 2-methyl suphonyl amino-4-isothiocynato methyl thiazole, glycine and aryl aldehydes in acetic acid (Scheme1). Intermediate 2-Amino-4-(isothiocynatomethyl) thiazole (2) has been synthesized from 2-amino-4-chloromethyl thiazole hydrochloride (1) by nucleophilic displacement of chlorine with isothiocynate. Synthesized intermediates and final compounds were characterized by I.R, ¹HNMR, MASS spectroscopic techniques and C, H, N and S analysis. Synthesized final compounds were evaluated for in vitro anti-inflammatory activity by HRBC membrane stabilization method. Most of the synthesized compound exhibited good anti-inflammatory activity as compared to standard Diclofenac sodium.