Synthesis, Characterization and In-Vitro Antidiabetic Studies of Vanadium Complexes derived from N2O₂ donor Ligands

Trace elements are very essential for human health. Chemists have been attracted to prepare new potent inorganic pharmaceutical agents and these are used to treat chronic diseases. Vanadium complexes are used as good diagnostic tool for diabetes mellitus. The progress in the field of development in orally active antidiabetic vanadium complexes with different coordination structures using experimental diabetic animals and enzyme inhibitory action (α-amylase inhibition). In the present study we synthesized, characterized and evaluated % αamylase inhibition by vanadium complexes having tetradentate Schiff base ligands-H₂L₁, H₂L₂ and H₂L₃. The mole ratio for preparation of complexes is 1: 1. The synthesized vanadium complexes were characterized by sophisticated techniques and screened for antidiabetic activity by α-amylase inhibition assay. The data assigned to conclude that H₂L₁ shows lowest IC₅₀ value 0.786 mg/ml while L₂V shows highest IC₅₀ value 0.626 mg/ml.