Synthesis and Anti-Bacterial Activity of 1, 4-Dihydropyridine Derivatives Embedded with Chromone and Dimedone Based Hybrids

1, 4-dihydropyridines (1, 4-DHPs) represent a class of compounds possessing various structural modified derivatives, particularly amongst natural products and bioactive agents. The clinically important drugs such as Nicardipine, Nifedipine, Nimodipine, Felodipine, Isradipine and Amlodipine appeared on the market with new active functional group in their main skeleton. Due to their importance in medicinal chemistry, the present paper describes the synthesis of eight new 1, 4-dihydropyridine derivatives based on the coupling of 2-amino-4Hchromen-4-one, benzaldehyde and 5-substituted dimedones. These derivatives were evaluated for antibacterial activity (at concentration of 30 μg/mL) with reference to the antibiotic drug streptomycin. The screening results revealed that compounds with R =-CH₃, (−CH₃)₂ and-CH₂-CH₃ (7b, 7c and 7d) showed antibacterial good activity.