Microwave assisted synthesis of 1, 3, 5-triazine containing [1, 8]naphthyridine derivatives
Abstract
2-Cyclopropyl-[1, 8]naphthyridine-3-carboxylic acid ethyl ester (1) reacts with different aromatic aldehydes yields N-(2-Cyclopropyl-[1, 8]naphthyridine-3-carbonyl)-guanidine (2). which on further treatment with aromatic nitriles to yield 4-(2-Cyclopropyl-[1, 8]naphthyridin-3-yl)-6-phenyl-[1, 3, 5]triazin-2-ylamine (3a-e).
Keywords
1, 8-naphthyridine, nitriles, triazine, antibacterial activity
