Asian Journal of Research in Chemistry
  • Year: 2018
  • Volume: 11
  • Issue: 1

Synthesis of Tetrahydroquinoline derivatives via One Pot Multi-component (4+2) Cycloaddition (Povarov) Reaction

1Department of Chemistry, Doshi Vakil Arts and G.C.U.B. Science and Commerce College, Goregaon-Raigad, Maharashtra-India

2Department of Chemistry, Dr. Rafiq Zakaria College for Women, Navkhanda, Jublee Park, Aurangabad, Maharashtra-India

*Corresponding Author E-mail: chemistryp141286@gmail.com

Online published on 26 March, 2018.

Abstract

In the presence of InCl3 as a catalyst one-pot (4π+2π) cycloaddition reaction of aromatic aldehydes, arylamines and DHF in ethanol proceeded smoothly to give tetrahydroquinoline derivatives (4a-4j) in excellent yields. Advantages of this method are shorter reaction time and biologically important.

Keywords

Tetrahydroquinoline Derivatives, Aromatic Aldehyde, Povarov reaction and Reflux