Preparation and Characterization of Flurbiprofen Co-crystals By Using Factorial Design

Flurbiprofen is a non-steroidal anti-inflammatory BCS class II drug of low solubility and high permeability. Pharmaceutical co-crystals of Flurbiprofen were prepared with co-crystal former as benzoic acid to improve drug its physicochemical parameters. Solvent drop grinding method was found to be successful to prepare Flurbiprofen co-crystals. All new crystalline forms were characterized by IR spectroscopy, differential scanning calorimetry, and X-ray diffraction to confirm their purity and homogeneity. Co-crystals with benzoic acid showed a faster powder dissolution rate as compared with pure active pharmaceutical ingredient (API). Co-crystals of Flurbiprofen with benzoic acid showed increase in solubility by 6.68 fold as compared with pure active pharmaceutical ingredient (API). The study showed that co-crystals is an emerging alternative to modify and enhance physicochemical properties of drug to enhance their pharmaceutical properties.