1Department of Chemistry, S. M. P. Mahavidyalaya, Murum-413605, Dist.-Osmanabad, India
2Department of Chemistry, KMC College, Khopoli, Maharashtra-410203, India
3Shivneri College, Shirur Anantpal, Dist. Latur, Maharashtra-413544, India
4Research Laboratory for Pure and Applied Chemistry, M. M. College, Nilanga, Dist. Latur, MH-413521, India
*Corresponding Author E-mail: amritkund_jk@rediffmail.com
Online published on 2 June, 2018.
5, 5-Diphenylhydantoin (Phenytoin) is a well-known anticonvulsant and antiarrhythmic drug which may cause unwanted side effects. In order to avoid the adverse effects of phenytoin, especially on the central nervous and cardiovascular systems, a small series of amine derivatives (Mannich bases) were designed containing phenytoin nucleus. For this synthesis we follow green methodology during synthesis of phenytoin from benzyl and urea.
Phenytoin, Mannich bases, Green methods, Benzyl
