Asian Journal of Research in Chemistry

Antibacterial and antifungal agents are widely used in the management of infectious disease but most of them have developed resistance to micro-organism. To overcome this problem and to lower the side effects, many approaches can be utilized. In this article, the mode of action of antimicrobial agents and their mechanisms of resistance is discussed by synthesized different oxazoline analogues (3a-n). The series was evaluated for antimicrobial and antifungal activity to calculate zone of inhibition fallowed by MIC value of some selected compounds which show more zone of inhibition. Further, One Way Analysis of Variance (ANOVA) followed by Duncan multiple range test for pair-wise comparison is used to study the significant different in mode of action of different antifungal and antibacterial activities resistance data to different bacteria and fungi, (3a-n). The test revealed that compound 3e with a chloro group at ortho position in phenyl ring was found to be more potent among the series 3a-n. The results showed that synthesized compound 3e might be a potential antibacterial agent in near future.