Asian Journal of Research in Chemistry

  • Year: 2018
  • Volume: 11
  • Issue: 3

Absolute configuration of boceprevir chiral fragment-B by chiral chromatographic, spectroscopic, thermal and crystallization techniques.

  • Author:
  • Nagaraju Rajana1,3,, V. Pallavi1, P. Madhavan1, H. Rama Mohan1, J. Moses Babu2, K. Basavaiah3
  • Total Page Count: 10
  • Page Number: 671 to 680

1Technology Development Center, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd, Miyapur, Hyderabad, 500049, India

2Integrated Product Development Organization, Dr. Reddy's Laboratories, Innovation Plaza, Bachupally, Telangana, 500072, India

3Department of Inorganic & Analytical Chemistry, Andhra University, Visakhapatnam (AP), 530003, India

*Corresponding Author E-mail: nagarajurajana@drreddys.com, nagarajrajana@gmail.com

Online published on 21 August, 2018.

Abstract

During reverse phase chromatography, the chiral fragment-B of Boceprevir i.e methyl (1R, 2S, 5S)-6, 6-dimethyl3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride was separated along its cis isomer, acid impurity and ester impurity. The R and S isomers of Trans isomers were separated by chiral chromatography; the chiral S isomer was characterized by the 1D NMR, FT-IR, Mass, SOR, X ray studies and differential scanning colorimetry.

A chiral fragment-B of Boceprevir

Keywords

Boceprevir, Absolute configuration, 1D NMR, Chiral chromatography