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*Corresponding Author E-mail: nagarajurajana@drreddys.com, nagarajrajana@gmail.com
During reverse phase chromatography, the chiral fragment-B of Boceprevir i.e methyl (1R, 2S, 5S)-6, 6-dimethyl3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride was separated along its cis isomer, acid impurity and ester impurity. The R and S isomers of Trans isomers were separated by chiral chromatography; the chiral S isomer was characterized by the 1D NMR, FT-IR, Mass, SOR, X ray studies and differential scanning colorimetry.
A chiral fragment-B of Boceprevir
Boceprevir, Absolute configuration, 1D NMR, Chiral chromatography