Asian Journal of Research in Chemistry

  • Year: 2018
  • Volume: 11
  • Issue: 3

Absolute configuration of boceprevir chiral fragment-B by chiral chromatographic, spectroscopic, thermal and crystallization techniques.

  • Author:
  • Nagaraju Rajana1,3,, V. Pallavi1, P. Madhavan1, H. Rama Mohan1, J. Moses Babu2, K. Basavaiah3
  • Total Page Count: 10
  • Page Number: 671 to 680

1Technology Development Center, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd, Miyapur, Hyderabad, 500049, India

3Department of Inorganic & Analytical Chemistry, Andhra University, Visakhapatnam (AP), 530003, India

2Integrated Product Development Organization, Dr. Reddy's Laboratories, Innovation Plaza, Bachupally, Telangana, 500072, India

Abstract

During reverse phase chromatography, the chiral fragment-B of Boceprevir i.e methyl (1R, 2S, 5S)-6, 6-dimethyl3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride was separated along its cis isomer, acid impurity and ester impurity. The R and S isomers of Trans isomers were separated by chiral chromatography; the chiral S isomer was characterized by the 1D NMR, FT-IR, Mass, SOR, X ray studies and differential scanning colorimetry.

A chiral fragment-B of Boceprevir

Keywords

Boceprevir, Absolute configuration, 1D NMR, Chiral chromatography