Asian Journal of Research in Chemistry

Cyclic aromatic secondary amines, like phthalimides, and related compounds possess structural features, which makes them to exert potential biological activities and pharmaceutical applications. A new Mannich base has been synthesized from phthalimide and its transition metal complexes also were prepared. The Mannich base ligand was synthesized by using phthalimide, formaldehyde and piperidine. The ligand as well as the metal complexes were characterized by various physical methods. The structure of the synthesized compounds are confirmed by UV, IR, and ¹H NMR spectroscopic techniques. The antimicrobial activity of the ligand and the complexes were examined using different bacteria by disc diffusion technique.