A non-Aqueous Potentiometric Titration Method for Validation of Secnidazole from Pharmaceutical Dosages

A sensitive non-aqueous potentiometric titration method was developed for quantitative determination of secnidazole from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r²> 0.999) between 20% to 100% of 500 mg of drug substance weight. The percentage recovery of secnidazole in the optimized method was between 99.643 to 100.505%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.