Microwave Assisted Synthesis, Characterization and Antibacterial Study of Some Novel Schiff's Bases and Azetidinone Compounds derived from Ibuprofen

This work involves synthesis of some new heterocyclic compounds including azetidinone compounds. The new Schiff bases derived from ibuprofen, which was synthesized by microwave irradiation of ibuprofen with hydrazine hydrate in absolute ethanol and this amino compound condensation with different aromatic aldehydes in absolute ethanol. Azetidinone compounds were synthesized by cycloaddition reaction of chloroacetyl chloride to imine group of Schiff bases in dry benzene. M.P., TLC, CHN, UV, FTIR and NMR spectroscopy has characterized all the synthesized compounds. The biological screening data of the synthesized compounds were also studied.