In vitro and Molecular Docking Studies of DPPH with Phoenix dactylifera L. (Deglet-Nour) Crude Fruits extracts and Evaluation of their Antioxidant Activity

Uses edible parts of date palm (Phoenix dactylifera L) fruits from Algeria were analyzed to determine their phenolic compound and antioxidant activities using DPPH, FRAP assay and molecular docking. In this paper, in-silico and in-vitro studies were used to study interaction Enzyme-Compounds and evaluate antioxidant activities of compounds. The results show that the date fruit rich in the total phenolic content was found Gallic acid, the flavonoid: quercetin and condensed tannins of catechin. The antioxidant activity ranged between 64, 46–91, 3 for DPPH (%) and 0, 194-14, 923μg AAE/0.5mg extract for FRAP. In-silico analysis was an agreement with in-vitro in which phenolic compounds showed more negative free energy against standard drug and bound with catalytic residues of Kinase. The findings provide evidence that date fruit has potential as a natural source of antioxidant with ethyl acetate showing to be the best extracting with corresponding higher antioxidant activities.