Asian Journal of Research in Chemistry

A simple precise, rapid accurate and sensitive titration method was developed for quantitative determination of isoxsuprine hydrochloride in pharmaceutical dosage form. The titration was carried out using standardized 0.1 N sodium hydroxide solution. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r² > 0.99) between 10% to 50% of 500 mg of drug, substance weight. The percentage recovery of isoxsuprine hydrochloride in the optimized method was 99.02% to 99.84%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different laboratories.