A Validated Potentiometric titration method for Quantitative Determination of Isoxsuprine hydrochloride from Pharmaceutical Preparation

A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of isoxsuprine hydrochloride from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with %RSD <1 (n = 6). The method showed strict linearity (r² > 0.9999) between 10% to 50% of 0.500mg of drug substance weight. The percentage recovery of isoxsuprine hydrochloride in the optimized method was between 98.66 to 99.95%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.