Application of Simultaneous Equation method for estimation of Sacubitril and Valsartan in Combined Dosage Form

A simple, specific, sensitive and accurate spectrophotometric method was developed for the determination of Sacubitril and Valsartan in combined dosage form by UV spectrophotometry using simultaneous equation method. Sacubitril and Valsartan showed the absorption maxima at 230 nm and 290 nm respectively in methanol. The linearity for a sacubitril was in the range of 2 - 20 μg/ml with correlation coefficient 0.999 and for valsartan in the range of 2- 50 μg/ml with correlation coefficient 0.999. The method was validated in terms of linearity, precision, accuracy, LOD and LOQ. The method is simple, convenient and suitable for the simultaneous estimation of Sacubitril and Valsartan in combined dosage form.