Asian Journal of Research in Chemistry
  • Year: 2023
  • Volume: 16
  • Issue: 6

Triphenylphosphine as an efficient and reusable organocatalyst for the synthesis of substituted pyrano[2,3-c]pyrazoles

  • Author:
  • Rajasekar Perumal, Panduragan Baskaran, Balaji Bathrinarayanan, Syed Sheik Mansoor*
  • Total Page Count: 5
  • Published Online: Feb 13, 2024
  • Page Number: 433 to 437

Research Department of Chemistry, Bioactive Organic Molecule Synthetic Unit, C. Abdul Hakeem College (Autonomous), Melvisharam – 632 509

*Corresponding Author E-mail: mansoorcah@gmail.com

Online Published on 13 February, 2024.

Abstract

Triphenylphosphine (PPh3) efficiently catalyzes the three-component synthesis of 6-amino-4-aryl-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazoles starting from 3-methyl-1-phenyl-2-pyrazolin-5-one, aromatic aldehydes and malononitrile. The method provided several advantages such as mild conditions, good to excellent yields, easily available catalyst and simple work procedure.

Keywords

6-Amino-4-aryl-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazoles, 3-Methyl-1-phenyl-2-pyrazolin-5-one, Aromatic aldehyde, Malononitrile, Triphenylphosphine